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Monday, May 20, 2019

NEWS 20 May 2019

NEWS FROM USA

505(b)2 NDA APPROVALS

Approval Date

Product Name

NDA Sponsor

Brand Name

Prescribing information

17 May 2019

Midazolam Nasal Spray

Proximagen 

Nayzilam

Link

 

New PED (pediatric) exclusivity listing in the orange book

Drug

Innovator

Brand Name

PED exclusivity expiration date

Tavaborole topical solution

Anacor Pharma

Kerydin

7 Jan. 2020*

*Because of PED, NCE exclusivity of Tavaborole is extended by 6 months. Earlier NCE exclusivity of Tavaborole was set to expire on 7 July 2019.

 

ANDA APPROVALS

 

Approval Date

Drug Product

ANDA

Sponsor

Corresponding RLD

Number Of Other Approved Generics

14 May 2019

Fulvestrant Injection

Sandoz 

Faslodex

(Astrazeneca)

One

(Amneal)

14 May 2019

Albendazole Tablets

Edenbridge Pharms

Albenza

(Impax)

Three

14 May 2019

Glycopyrrolate Injection

Sandoz 

Glycopyrrolate

(West-Ward)

Ten

15 May 2019

Zoledronic Acid Injection

Shilpa Medicare 

Zometa

(Novartis)

More Than 10

16 May 2019

Docetaxel Injection

Shilpa Medicare 

Taxotere

(Sanofi)

Eight

20 May 2019

Azacitidine Injection

Panacea Biotec

Vidaza

(Celgene)

Eight

 

TENTATIVE ANDA APPROVALS

Approval Date

Drug

Company

17 May 2019

Lurasidone Hydrochloride

Teva 

17 May 2019

Cinacalcet Hydrochloride

Alkem 

17 May 2019

Amphetamine Aspartate; Amphetamine Sulfate; Dextroamphetamine Saccharate; Dextroamphetamine Sulfate

Sun Pharma 

 

USFDA INSPECTION

 

Cipla (Indore facility): Cipla provided update on USFDA inspection at Indore  Indore manufacturing facility

-         USFDA conducted a post-approval inspection at our Indore facility from 13th May to 17th May, 2019.

-         The inspection was ended with zero observation.

-         Press Release: Link

 

Alkem Lab (Baddi Facility): Alkem provided update on USFDA inspection at Baddi manufacturing facility.

-         USFDA had conducted an inspection at the Company's manufacturing facility located at Baddi, India from 13th May, 2019 to 17th May, 2019.

-         At the end of the inspection, Company has received a Form 483 with four (4) observations.

-         Press Release: Link

 

Aurobindo (Unit I, IX and XI): Aurobindo provided update on USFDA inspection at API manufacturing facilities.

-         Aurobindo has received letters from the USFDA classifying the inspections concluded at our API facilities of Unit I and XI and intermediates facility of unit IX in February 2019 as Official Action Indicated (OAI).

-         The Company has already submitted its initial response to USFDA.

-         The Company said they are confident that these OAI classifications will not have an impact on disruption of supplies or the revenue from operations of these facilities.

-         Press Release: Link

 

Lupin (Aurangabad Facility): U.S. FDA completes inspection of Lupin’s Aurangabad facility.

-         The inspection was carried out from May 6 to May 15, 2019.

-         The inspection at the Aurangabad facility closed with three observations.

-         Press Release: Link

                       

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