Valtoco is the first and only diazepam nasal spray for seizure cluster rescue.
Before Valtoco, Diazepam was already available as oral tablets, oral solution, injections and rectal gel.
As mentioned on Valtoco’s website, “VALTOCO is a small, portable, and discreet nasal spray created for safe administration by nonmedical care partners, like family, friends, and coworkers.” See below approval details of Valtoco
Approval date: 10 Jan. 2020
Brand name: Valtoco
Innovator: Neurelis
Route and Dosage form: Nasal spray
Strengths: 5 mg/spray, 7.5 mg/spray and 10 mg/spray
Indication: for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (i.e., seizure clusters, acute repetitive seizures) that are distinct from a patient’s usual seizure pattern in patients with epilepsy 6 years of age and older.
Formulation: Valtoco utilizes Neurelis’ Intravail® technology.
Click here to read more about Intravail® technology.
Excipients employed in Valtoco: benzyl alcohol (10.5 mg per 0.1 mL), dehydrated alcohol, n-dodecyl beta-D-maltoside, and vitamin E.
Prescribing information: Available here
Orange book information: Available here
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